1 2 3 4 5
     For your own scientific reference, we encourage you to access the following links                       pertaining to the citations above:      Publication from The Journal of Clinical Investigation. “Topical hypochlorite ameliorates NF-      kB-mediated skin diseases in mice”  www.jci.org/articles/view/70895      Publication from Puget Sound Blood Center and UW Medical School. “Oxidative modification        of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13”       www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/      Publication in the US National Library of Medicine, National Institutes of Health. “Fibrin Clot      Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in      Fibrinogen”  www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/      Publication from The Journal of Immunology. “Hypochlorous Acid: A Natural Adjuvant That      Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity”      www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9-98f5-770ee2b1f3eb      Publication from Medscape Multispecialty. “Hypochlorous Acid: An Ideal Wound Care Agent        With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency”     www.medscape.com/viewarticle/838158
The    proven    benefits    of    HOC l     and    its    varied    applications    are    well-known    in    the    world    of science.    A    simple    internet    search    will    yield    thousands    of    publications    in    peer    reviewed journals    on    the    production    of    HOC l     in    vivo,    and    several    hundred    on    the    use    of    ECA    in environmental protection. A review of these outstanding scientific discoveries regarding the attributes of HOCl will show the following citations: reduces skin aging 1 makes blood clot in wounds 2 causes fibrinogen oxidation, leads to firmer clots and longer clot lysis period 3 stimulates immunity to germs 4 produces powerful local stimulants of wound healing and germ killing 4 makes new skin cells grow over wounds and reorganizes scar fibers 5 leads to long lasting local effects in the body 5 As   an   antimicrobial,   antiviral   and   antifungal,   HOC l    hurries   healing   by   signaling   oxygenation and   epithelial   knitting,   while   working   to   mitigate   scarring.   In   addition   to   this,   HOC l    solution works   to   clear   a   myriad   of   skin   issues   and   conditions,   is   safe   for   all   mucosal   contact,   and   can be misted to permeate small crevices for effective odor control and sanitation.
The   positive   effects   of   HOC l    on   the   human   body,   both   inside   and   out,   have   been   studied   and recognized by medical scientists worldwide for over 100 years.
HOC l   is a natural part of our internal defense system and is produced in      our   white   blood   cells   as   a   component   that   works   to   fight   infection,   control responses to injury, and enhance healing. When     produced     outside     the     body,     HOC l      is     an     electrolyzed, antimicrobial,    biocide    solution    that    inactivates    pathogens    such    as bacteria, viruses, spores, and fungi. HOC l    is   safe   for   use   on   humans   and   animals,   and   its   proven   benefits   and   varied   applications are     well-known     in     the     world     of     science.     HOC l      is     a     product     of     normal     physiological mechanisms   in   the   body   that   works   as   part   of   the   healthy   response   to   injury   and   recover,   and when   applied   topically,   there   is   no   bubbling   or   tingling   sensation,   unlike   many   other   topically applied    solutions    that    sting,    irritate    or    aggravate    tissue    damage    at    wound    sites.    HOC l   consistently    shows    no    adverse    effects,    only    a    soothing,    steady    control    over    the    healing process that quickly become evident.  
BRIOTECH’S SCIENTIFIC  BREAKTHROUGH
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
FDA FACILITY REG #3012261723 | EPA #93108
A   cascade   of   changes   comes   about   with   this   HOC l    production,   including   the   production   of secondary    signaling    molecules,    speedy    initiation    of    local    clotting    to    seal    the    site,    and eventually   a   controlled   organization   of   fibers   laid   down   in   the   reorganizing,   healing   process. HOC l   can    even    enhance    and    hype    up    the    local    processes    that    lead    to    specific    immune reactions (antibody formation) against invading pathogens. The   mechanism   of   HOC l    production   from   salt   in   the   body   involves   intracellular   enzymes,   but outside   the   body   the   process   can   be   mimicked   by   using   controlled   application   of   electrical energy instead an electrochemical activation (ECA) process.
Harmful   pathogens   (bacteria,   spores   and   viruses)   can   be   found   all around    us in    the    air,    on    food,    plants,    animals,    and    on    inanimate surfaces.   The   human   body   uses   innate,   non-specific   mechanisms   as the   first   line   of   defense   against   injury   and   infection.   The   skin   itself, and   mucous   secretions   at   epithelial   membranes   are   both   important elements   of   innate   resistance.   But   when   these   are   breached,   HOC l   is      immediately      generated      in      response      as      the      key      chemical component of innate immunity. White   blood   cells   move   out   of   the   blood   vessels   at   the   wound   site, sensing   invaders   presence   through   chemical   signals.   There   they   set about   orchestrating   defenses.   In   a   burst   of   biochemical   activity the “oxidative burst” white blood cells use the chloride component of      their   normal   salt   content   and   generate   HOC l .   This   works   both   inside   vacuoles   (phagosomes) that   form   around   ingested   microbes,   and   in   the   extracellular   tissue   environment   to   marshall the necessary forces of antimicrobial attack and tissue defense.   
Phagocytosis   was   discovered   by microbiologist    Élie    Metchnikoff in     the     1880s,     who     won     the Nobel Prize for his discovery.
While   the   100   year   history   of   Hypochlorous   Acid   (HOC l )   has   provided   indisputable   evidence of    its    efficacy    in    healing    and    use    in    disinfection,    and    over    500    peer-reviewed,    published papers   universally   document   significant   beneficial   results,   the   widespread   use   of   HOC l    has remained   fairly   stagnant,   and   the   primary   limiting   factor   to   broad   adoption   of   this   important technology, historically, has been due to its lack of stability. With   that   knowledge,   and   the   bottom-line   mission   to   fundamentally   change   the   discussion   of health,     healing     and     disinfection     around     the     world,     BRIOTECH     dove     into     all     things HOC l —science,   technology,   equipment,   properties   and   production.   Through   eight   years   of research,   BRIOTECH   has   brought   HOC l    technology   to   the   forefront   through   trade-secret developments   in   properties   and   production   which   have   been   documented   and   published   as scientific breakthroughs in both efficacy and stability.  BRIOTECH     HOCL     products     are     unique ;     and     our     difference     stems     from     our     purity. BRIOTECH   is   HOC l   in   its   purest   form.   While   many   other   HOC l    producers   talk   about   purity, you   can   simply   read   their   labels   to   identify   the   cocktail   of   chemicals   inside.   The   importance   of this   is   realized   in   the   fact   that   purity real   purity—provides   unmatched   safety,   efficacy,   and stability;   and   the   importance   of   this   is   realized   in   the   fact   that   only   BRIOTECH   has   been proven to eliminate the world’s most dangerous and hardiest pathogen.
The   following   search   suggestions   will   provide   you   with   a   myriad   of   resource   materials,   such   as medical   publications,   case   studies   and   news   articles   relative   to   hypochlorous   acid   (HOC l ).   We have   systematically   researched   this   material   over   the   years   to   realize   the   facts   and   further our   knowledge   and   understanding   of   this   wonderful   product.   As   a   result   of   our   research,   we are   encouraged   by   the   affirmation   of   the   scientific   community   as   to   the   positive   effects   of HOC l  on humans, animals, and the environment.
“Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice” www.jci.org/articles/view/70895 “Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13” www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979 “Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen” www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520 “Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross- Priming, and the Induction of Adaptive Immunity” www.jimmunol.org/content/184/2/824.full “Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency” www.medscape.com/viewarticle/838158 “The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is ‘Tragically Inadequate’” www.marketwatch.com/story/the-national-necrotizing-fasciitis-foundation “Activated and Electrolyzed Water: A Brief Review of a New Generation of Cleaners and Sanitizing Agents.” www.foodsafetymagazine.com/magazine-archive1/augustseptember-2010 “Stabilized Hypochlorous Acid: Its Role In Decreasing Tissue Bacterial Bioburden” www.citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.9102 “The Inhibition of Bacterial Growth By Hypochlorous Acid. Possible role in the bactericidal activity of phagocytes.” www.ncbi.nlm.nih.gov/pmc/articles/PMC1135139 “Hypochlorous Acid as a Potential Wound Care Agent” www.ncbi.nlm.nih.gov/pmc/articles/PMC1853323 “Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria Monocytogenes” www.ncbi.nlm.nih.gov/pubmed/10473453 “Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment” www.ncbi.nlm.nih.gov/pmc/articles/PMC2302602
1 2 3 4 5 6 7 8 9 10 11 12
l
HOCl O H Cl
BRIOTECH’S SCIENTIFIC BREAKTHROUGH
2
     For your own scientific reference, we encourage you to             access the following links pertaining to the citations above:        Publication from The Journal of Clinical Investigation. “Topical          hypochlorite ameliorates NF-kB-mediated skin diseases in mice”         www.jci.org/articles/view/70895        Publication from Puget Sound Blood Center and UW Medical School.        “Oxidative modification of von Willebrand factor by neutrophil        oxidants inhibits its cleavage by ADAMTS13”          www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/        Publication in the US National Library of Medicine, National        Institutes of Health. “Fibrin Clot Structure and Mechanics Associated        with Specific Oxidation of Methionine Residues in Fibrinogen”        www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/        Publication from The Journal of Immunology. “Hypochlorous Acid: A        Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming,        and the Induction of Adaptive Immunity”        www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9-98f5        Publication from Medscape Multispecialty. “Hypochlorous Acid: An        Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm,               and Wound Healing Potency”         www.medscape.com/viewarticle/838158
The   proven   benefits   of   HOC l    and   its   varied   applications   are well-known   in   the   world   of   science.   A   simple   internet   search will   yield   thousands   of   publications   in   peer   reviewed   journals on   the   production   of   HOC l    in   vivo,   and   several   hundred   on the use of ECA in environmental protection. A      review      of      these      outstanding      scientific      discoveries regarding    the    attributes    of    HOC l    will    show    the    following citations: reduces skin aging 1 makes blood clot in wounds 2 causes fibrinogen oxidation, leads to firmer clots and longer clot lysis period 3   stimulates immunity to germs 4 produces powerful local stimulants of wound healing and germ killing 4 makes new skin cells grow over wounds and reorganizes scar fibers 5 leads to long lasting local effects in the body 5 As    an    antimicrobial,    antiviral    and    antifungal,    HOC l     hurries healing     by     signaling     oxygenation     and     epithelial     knitting,            while     working     to     mitigate     scarring.     In     addition     to     this,               HOC l     solution    works    to    clear    a    myriad    of    skin    issues    and conditions,   is   safe   for   all   mucosal   contact,   and   can   be   misted to    permeate    small    crevices    for    effective    odor    control    and sanitation.
HOC l    is   a   natural   part   of   our   internal   defense system   and   is   produced   in   our   white   blood   cells as   a   component   that   works   to   fight   infection, control    responses    to    injury,    and    enhance healing. When   produced   outside   the   body,   HOC l    is   an   electrolyzed, antimicrobial,    biocide    solution    that    inactivates    pathogens such as bacteria, viruses, spores, and fungi. HOC l    is   safe   for   use   on   humans   and   animals,   and   its   proven benefits   and   varied   applications   are   well-known   in   the   world of     science.     HOC l      is     a     product     of     normal     physiological mechanisms    in    the    body    that    works    as    part    of    the    healthy response   to   injury   and   recover,   and   when   applied   topically, there   is   no   bubbling   or   tingling   sensation,   unlike   many   other topically    applied    solutions    that    sting,    irritate    or    aggravate tissue   damage   at   wound   sites.   HOC l    consistently   shows   no adverse    effects,    only    a    soothing,    steady    control    over    the healing process that quickly become evident.  
1 3 4 5
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH, ITS LOGOS, LANGUAGE & IMAGES ARE TRADEMARKS & COPYRIGHT PROPERTY OF BRIOTECH, INC. & ITS AFFILIATES. © 2013-2018
FDA FACILITY REG #3012261723 | EPA #93108
A      cascade      of      changes      comes      about      with      this      HOC l   production,   including   the   production   of   secondary   signaling molecules,   speedy   initiation   of   local   clotting   to   seal   the   site, and   eventually   a   controlled   organization   of   fibers   laid   down in   the   reorganizing,   healing   process.   HOC l    can   even   enhance and   hype   up   the   local   processes   that   lead   to   specific   immune reactions (antibody formation) against invading pathogens. The   mechanism   of   HOC l    production   from   salt   in   the   body involves    intracellular    enzymes,    but    outside    the    body    the process   can   be   mimicked   by   using   controlled   application   of electrical    energy    instead    —    an    electrochemical    activation (ECA) process.
Harmful    pathogens    (bacteria,    spores    and viruses)   can   be   found   all   around   us in   the air,      on      food,      plants,      animals,      and      on inanimate   surfaces.   The   human   body   uses innate,   non-specific   mechanisms   as   the   first line   of   defense   against   injury   and   infection. The    skin    itself,    and    mucous    secretions    at epithelial    membranes    are    both    important elements    of    innate    resistance.    But    when these     are     breached,     HOC l      is     immediately     generated     in response as the key chemical component of innate immunity. White   blood   cells   move   out   of   the   blood   vessels   at   the   wound site,    sensing    invaders    presence    through    chemical    signals. There   they   set   about   orchestrating   defenses.   In   a   burst   of biochemical   activity the   “oxidative   burst” white   blood   cells use    the    chloride    component    of    their    normal    salt    content            and     generate     HOC l .     This     works     both     inside     vacuoles (phagosomes)    that    form    around    ingested    microbes,    and    in the      extracellular      tissue      environment      to      marshall      the necessary forces of antimicrobial attack and tissue defense  
Phagocytosis was discovered by microbiologist Élie Metchnikoff in the 1880s, who won the Nobel Prize for his discovery.
While    the    100    year    history    of    Hypochlorous    Acid    (HOC l )      has   provided   indisputable   evidence   of   its   efficacy   in   healing and     use     in     disinfection,     and     over     500     peer-reviewed, published   papers   universally   document   significant   beneficial results,    the    widespread    use    of    HOC l     has    remained    fairly stagnant,   and   the   primary   limiting   factor   to   broad   adoption of   this   important   technology,   historically,   has   been   due   to   its lack of stability. With     that     knowledge,     and     the     bottom-line     mission     to fundamentally   change   the   discussion   of   health,   healing   and disinfection    around    the    world,    BRIOTECH    dove    into    all things    HOC l —science,    technology,    equipment,    properties and       production.       Through       eight       years       of       research, BRIOTECH   has   brought   HOC l    technology   to   the   forefront through      trade-secret      developments      in      properties      and production     which     have     documented     and     published     as scientific breakthroughs in both efficacy and stability. BRIOTECH   HOCL   products   are   unique ;   and   our   difference stems    from    our    purity.    BRIOTECH    is    HOC l     in    its    purest form.   While   many   other   HOC l    producers   talk   about   purity, you   can   simply   read   their   labels   to   identify   the   cocktail   of chemicals    inside.    The    importance    of    this    is    realized    in    the      fact   that   purity   —   real   purity   —   provides   unmatched   safety, efficacy,     and     stability;     and     the     importance     of     this     is          realized   in   the   fact   that   only   BRIOTECH   has   been   proven           to     eliminate     the     world’s     most     dangerous     and     hardiest pathogen.
PROVEN PURE AND ALWAYS STABLE, BRIOTECH HOCL PRODUCTS OFFER A FUTURE  OF ENDLESS POSSIBILITIES.
The positive effects of HOCl on the human body, both inside and out, have been studied and recognized by medical scientists worldwide for over 100 years.
“Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice” www.jci.org/articles/view/70895 “Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13” www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/ “Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen” www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/ “Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity” www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9- 98f5-770ee2b1f3eb “Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency” www.medscape.com/viewarticle/838158 “The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is ‘Tragically Inadequate’” www.marketwatch.com/story/the-national-necrotizing-fasciitis-foundation “Activated and Electrolyzed Water: A Brief Review of a New Generation of Cleaners and Sanitizing Agents.” www.foodsafetymagazine.com/magazine-archive1/augustseptember-2010 “Stabilized Hypochlorous Acid: Its Role In Decreasing Tissue Bacterial Bioburden” www.citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.9102 “The Inhibition of Bacterial Growth By Hypochlorous Acid. Possible role in the bactericidal activity of phagocytes.” www.ncbi.nlm.nih.gov/pmc/articles/PMC1135139/ “Hypochlorous Acid as a Potential Wound Care Agent” www.ncbi.nlm.nih.gov/pmc/articles/PMC1853323/ “Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria Monocytogenes” www.ncbi.nlm.nih.gov/pubmed/10473453 “Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment” www.ncbi.nlm.nih.gov/pmc/articles/PMC2302602/
1 2 3 4 5 6 7 8 9 10 11 12
The    following    search    suggestions    will    provide    you    with    a myriad   of   resource   materials,   such   as   medical   publications, case   studies   and   news   articles   relative   to   hypochlorous   acid (HOC l ).    We    have    systematically    researched    this    material over   the   years   to   realize   the   facts   and   further   our   knowledge and   understanding   of   this   wonderful   product.   As   a   result   of our   research,   we   are   encouraged   by   the   affirmation   of   the scientific   community   as   to   the   positive   effects   of   HOC l    on humans, animals, and the environment.
HOCl O H Cl
l