The breakthrough needed to overcome a critically important deficiency in infection control. A new, fast, convenient and safe method for decontamination of medical instruments, surfaces, and tissues by simple immersion in an aqueous solution. BRIO HOCL PrP Formula TM  is a proven anti-prion reagent to combat misfolded infectious proteins, and the recommended proprietary disinfection solution to combat all misfolded infectious proteins. This patent pending product is currently available  for research use.
 A BRIOTECH BREAKTHROUGH
BRIO   HOCL   PrP   Formula TM    is   a   certified   pure   formulation   of   hypochlorous   acid   that   contains no   buffers.   It   has   been   laboratory   tested   and   proven   to   be   the   world’s   first   safe   method   to eliminate   all   detectable   seeding   activity   of   misfolded   infectious   proteins,   and   is   safe   for   skin and mucosal contact.
Dodge: Exclusive Distribution for Funeral Service From    its    founding    in    1893,    Dodge    has    consistently    developed    and    delivered    innovative products    that    serve    the    needs    of    the    funeral    industry.    Since    its    early    years    with    the establishment   of   schools   to   teach   the   science   of   embalming,   to   the   more   current   introduction of   formaldehyde-free   chemicals,   Dodge   has   led   the   way.   Today,   Dodge,   a   fourth   generation family   business,   is   the   largest   provider   of   embalming   chemicals   and   supplies   with   subsidiaries and   distributors   located   throughout   the   world.   Briotech   Inc.   is   honored   to   partner   with   this industry    leader    for    exclusive    distribution    of    BRIO     HOCL    PrP    Formula TM     into    the    funeral service industry.
Dodge. Helping you make all the difference.
BRIO        HOCL    PrP    Formula TM     is    available    for    the    funeral    industry    through    Dodge    in    the following countries: 
Please contact your Dodge Sales Representative at their customer service line at 800.443.6343 or email them at:  custserv@dodgeco.com 
ACTIVE INGREDIENTBRIO HOCL Pure HOCL™, 0.03%
USA CANADA MEXICO EL SALVADOR COLUMBIA JAMAICA VIRGIN ISLANDS SPAIN PORTUGAL ITALY
SWEDEN UK IRELAND HOLLAND FRANCE GERMANY CZECHOSLOVAKIA BELGIUM POLAND HUNGARY ROMANIA
RUSSIA JAPAN SINGAPORE PHILIPPINES CAMBODIA VIETNAM AUSTRALIA GHANA NIGERIA UGANDA
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
# P R O V E N P U R E
FDA FACILITY REG #3012261723 | EPA #93108
BR I O T E C H ,  I N C . Woodinville, WA 98072, USA b r i o t e c h u s a . c o m
September 29th, 2016 11:02 AM PDT
P R E S S  R E L E A S E
NIH   Scientists   and   collaborators   report   that   Briotech   Inc.’s   proprietary   HOCl   formulation   rapidly inactivates   resistant   infectious   proteins,   known   as   prions,   that   cause   Mad   Cow,   Chronic   Wasting,   and Creutzfeldt–Jakob Disease, and are now implicated in Alzheimer’s and other chronic brain diseases WOODINVILLE,    Washington    (September    29,    2016)    Briotech    Inc.    today    announced    that    a    study published   in   the   current   issue   of   PLOS   Pathogens       proves   that   Briotech’s   unique   formulation   of   pure hypochlorous   acid   (HOCl)   inactivates   infectious   proteins,   known   as   prions,   that   cause   chronic   brain diseases in humans and animals.  Investigators   at   the   US   National   Institute   of   Allergy   and   Infectious   Diseases   (NIAID)   Rocky   Mountain Laboratories,   made   the   discovery   in   collaboration   with   researchers   at   the   University   of   Washington (UW)    Bothell,    UW    Seattle,    the    University    of    Verona    (Italy),        and    Briotech    Inc.    Their    findings demonstrate    that    Briotech’s    patent-pending    solution    (BrioHOCl TM )    quickly    and    safely    destroys prions, the most resistant infectious agents known to medical science. HOCl   is   made   naturally   in   human   white   blood   cells   as   a   key   part   of   the   body’s   internal   defense   system. It   works   as   the   first   line   of   defense   at   wound   sites   to   fight   infection.   Briotech’s   proprietary   Electro- Chemical    Activation    (ECA)    technology    enables    large-scale    production    of    this    powerful    natural compound for use in consumer and professional healthcare settings. “We’ve   been   able   to   synthesize   the   same   pure   substance   that   the   body   creates   to   defend   itself   as   a new   weapon   in   the   fight   against   infectious   disease,   and   it’s   a   game   changer   for   human   health,”   said Dan   Terry,   founder,   and   CEO   of   Briotech.   “With   broad   adoption   of   BrioHOCl TM ,   we   can   help   stop   the spread    of    many    infectious    diseases,    even    those    caused    by    the    most    highly    resistant    agents    ever discovered prions and   use   the   product   to   save   lives   and   improve   the   health   of   entire   communities around   the   world.   We’re   excited   to   have   this   research   published   in   PLOS   Pathogens ,   and   look   forward to   our   continued   collaboration   with   the   NIH   on   the   effects   of   BrioHOCl TM    on   emerging   infectious pathogens that threaten global health and safety.” DESTROYING PRIONS Prions   are   abnormal,   misfolded   body   proteins   that   go   out   of   control   and   begin   to   multiply   themselves, spreading   throughout   the   body   and   invading   the   brain.   Prions   are   most   commonly   transmitted   orally, but   can   also   contaminate   medical   and   surgical   instruments,   transplanted   tissues,   and   equipment   used in    food    processing.    A    new,    fast,    convenient    and    safe    method    for    decontamination    of    medical instruments,   surfaces,   and   tissues by   simple   immersion   in   an   aqueous   solution   of   Briotech’s   pure BrioHOCl TM can   overcome   a   critically   important   deficiency   in   infection   control   today.   It   can   mitigate risks, and limit liabilities related to healthcare procedures and hospital acquired diseases. Prion   diseases   are   most   widely   known   as   the   cause   of   Mad   Cow   Disease   (BSE).   Prions   also   cause Creutzfeldt-Jakob   Disease   (CJD)   in   humans,   a   fatal   dementia   with   a   long   incubation   period.   Recently, research   has   shown   that   most   other   chronic   degenerative   diseases   that   lead   to   dementia,   including Alzheimer’s,   result   from   prions.   Currently   untreatable,   and   inevitably   fatal,   controversy   swirls   around their   possible   transmissibility   as   referenced   in   Nature    ( nature.com/news/the-red-hot-debate-about- transmissible-alzheimers ) Prions    are    uniquely    resistant    to    the    disinfection    and    sterilization    procedures    in    common    use    in healthcare   practice   today.   Extreme   measures   are   needed.   Current   prion   decontamination   protocols are    hazardous    to    people,    damaging    to    instruments    and    surfaces,    and    therefore    impractical    for transmission   control.   “Briotech   has   developed   an   enabling   technology,   one   that   offers   for   the   first time   a   practical   and   safe   way   of   destroying   infectious   prions,   the   disease   agents   at   the   very   top   of   the food   chain   when   it   comes   to   resistance   to   disinfection   measures,”   said   Jeff   Williams,   PhD,   BVSc,   Chief Scientific   Officer   at   Briotech.   “We   believe   we’ve   just   exposed   the   tip   of   the   iceberg   when   it   comes   to revealing    the    full    potential    of    the    pure    HOCl     in    controlling    and    preventing    many    transmissible diseases.   That’s   so   important   today   when   rampant   antibiotic   resistance   is   challenging   established approaches   to   infectious   disease   management   all   over   the   world.   The   discovery   reported   in   PLOS Pathogens     has    opened    new    avenues    for    researchers    to    explore    in    understanding    the    relationship between   the   HOCl   made   in   the   brain,   its   possible   involvement   in   prion   inactivation   there,   and   the disease   processes   that   lead   to   dementia.   Understanding   those   processes   is   one   of   the   most   urgent priorities facing biomedical science at this time.” HOW IT WORKS BrioHOCl TM    is   easy   to   handle,   safe   for   both   users   and   treated   surfaces   and   is   environmentally   safe. Pure   HOCl,      used   in   the   PLOS   Pathogens    report,   is   reliably   stable   in   its   formulation   and   powerfully effective   against   a   wide   range   of   conventional   microbial   disease   agents.   The   solution   can   be   applied directly    to    skin    and    mucous    membranes,    hard    surfaces,    instruments,    or    safely    aerosolized    to decontaminate entire rooms. Briotech    manufactures    BrioHOCl TM     in    fully-automated    production    platforms    inside    20’    shipping containers,   enabling   production   and   distribution   of   a   consistent   and   pure   form   of   HOCl   virtually anywhere in the world. ABOUT BRIOTECH INCORPORATED Based   in   Woodinville,   WA,   the   company   was   founded   in   2013   to   commercialize   the   production   of pure    HOCl,    a    powerful,    safe,    naturally    occurring    substance,    effective    against    the    whole    range    of infectious   disease   pathogens   of   humans   and   animals,   and   to   make   it   readily   available   throughout   the world.   Briotech’s   introduction   of   transportable,   self-contained   manufacturing   systems   makes   high volume    production    of    consistent    and    reliable    HOCl    solutions    possible    for    the    first    time    ever.    Its proprietary   electrolysis   technology   creates   unique   formulations   of   stable   HOCl   for   a   wide   range   of applications   in   consumer,   medical,   agricultural   and   industrial   settings.   More   information   is   available   at briotechusa.com . ABOUT THE RESEARCH STUDY The   research   study   titled   “Inactivation   of   Prions   and   Amyloid   seeds   with   Hypochlorous   Acid”   appears in the current issue of PLOS Pathogens  here: dx.plos.org/10.1371/journal.ppat.1005914 BrioHOCl TM       treatment   led   to      a   high   level   of   inactivation   after   short   exposure   times   for   transmissible prions   of   CJD,   BSE,   and   CWD,   but   also   for   self-replicating   proteins   found   in   Alzheimer’s,   Parkinson’s and    other    dementias.    Infectivity    of    BrioHOCl TM   treated    scrapie    prions    in    mice    was    also    highly significantly reduced.
B R I O    H O C L   P r P   F O R M U L A  TM
U N M A T C H E D  I N  P U R I T Y  A N D  S T A B I L I T Y
a proprietary     PrP Formula TM          by Briotech
PROVEN EFFECTIVE FOR INACTIVATION OF PRIONS AND OTHER MISFOLDED INFECTIOUS PROTEINS FOR RESEARCH & INVESTIGATIONAL USE ONLY
®
“I   think   it   [BRIO      HOCL TM ]   will   have   an   extraordinary   important   application   in   the   world   Byron   Caughey,   a   senior   investigator   at   the   National   Institute   of   Allergy   and   Infectious   Diseases,              a division of the National Institutes of Health.
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
A BRIOTECH BREAKTHROUGH
BRIO    HOCL   PrP   Formula TM    is   a   certified   pure   formulation   of hypochlorous    acid    that    contains    no    buffers.    It    has    been laboratory    tested    and    proven    to    be    the    world’s    first    safe method     to     eliminate     all     detectable     seeding     activity     of misfolded     infectious     proteins,     and     is     safe     for     skin     and mucosal contact.
Dodge: Exclusive Distribution for Funeral Service From      its      founding      in      1893,      Dodge      has      consistently developed   and   delivered   innovative   products   that   serve   the needs   of   the   funeral   industry.      Since   its   early   years   with   the establishment   of   schools   to   teach   the   science   of   embalming, to     the     more     current     introduction     of     formaldehyde-free chemicals,    Dodge    has    led    the    way.    Today,    Dodge,    a    fourth generation     family     business,     is     the     largest     provider     of embalming    chemicals    and    supplies    with    subsidiaries    and distributors    located    throughout    the    world.    Briotech    Inc.    is honored    to    partner    with    this    industry    leader    for    exclusive distribution   of   BRIO      HOCL   PrP   Formula TM    into   the   funeral service industry.
BRIO      HOCL   PrP   Formula TM    is   available   through   the   Dodge Company, or its distributors, in the following countries:  
Please contact your Dodge Sales Representative at their customer service line at 800.443.6343 or email them at:  custserv@dodgeco.com 
SWEDEN UK IRELAND HOLLAND FRANCE GERMANY CZECHOSLOVAKIA BELGIUM POLAND HUNGARY ROMANIA
RUSSIA JAPAN SINGAPORE PHILIPPINES CAMBODIA VIETNAM AUSTRALIA GHANA NIGERIA UGANDA
USA CANADA MEXICO EL SALVADOR COLUMBIA JAMAICA VIRGIN ISLANDS SPAIN PORTUGAL ITALY
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
B R I O T E C H ,  I N C . Woodinville, WA 98072, USA b r i o t e c h u s a .c o m
September 29th, 2016 11:02 AM PDT
NIH   Scientists   and   collaborators   report   that   Briotech   Inc.’s proprietary    HOCl    formulation    rapidly    inactivates    resistant infectious   proteins,   known   as   prions,   that   cause   Mad   Cow, Chronic    Wasting,    and    Creutzfeldt–Jakob    Disease,    and    are now     implicated     in     Alzheimer’s     and     other     chronic     brain diseases WOODINVILLE,   Wash.   (September   29,   2016)   Briotech   Inc. today   announced   that   a   study   published   in   the   current   issue of   PLOS   Pathogens       proves   that   Briotech’s   unique   formulation of     pure     hypochlorous     acid     (HOCl)     inactivates     infectious proteins,   known   as   prions,   that   cause   chronic   brain   diseases in humans and animals.  Investigators    at    the    US    National    Institute    of    Allergy    and Infectious    Diseases    (NIAID)    Rocky    Mountain    Laboratories, made   the   discovery   in   collaboration   with   researchers   at   the University      of      Washington      (UW)      Bothell,      UW      Seattle,                                                                    the    University    of    Verona    (Italy),    and    Briotech    Inc.    Their findings       demonstrate       that       Briotech’s       patent-pending solution   (BrioHOCl TM )   quickly   and   safely   destroys   prions,   the most resistant infectious agents known to medical science. HOCl    is    made    naturally    in    human    white    blood    cells    as    a                                      key   part   of   the   body’s   internal   defense   system.   It   works   as the    first    line    of    defense    at    wound    sites    to    fight    infection. Briotech’s    proprietary    Electro-Chemical    Activation    (ECA) technology   enables   large-scale   production   of   this   powerful natural    compound    for    use    in    consumer    and    professional healthcare settings. “We’ve    been    able    to    synthesize    the    same    pure    substance          that   the   body   creates   to   defend   itself   as   a   new   weapon   in   the fight   against   infectious   disease,   and   it’s   a   game   changer   for human   health,”   said   Dan   Terry,   founder,   and   CEO   of   Briotech. “With   broad   adoption   of   BrioHOCl TM ,   we   can   help   stop   the spread   of   many   infectious   diseases,   even   those   caused   by   the most    highly    resistant    agents    ever    discovered prions and use   the   product   to   save   lives   and   improve   the   health   of   entire communities    around    the    world.    We’re    excited    to    have    this research   published   in   PLOS   Pathogens ,   and   look   forward   to our   continued   collaboration   with   the   NIH   on   the   effects   of BrioHOCl TM    on   emerging   infectious   pathogens   that   threaten global health and safety.” DESTROYING PRIONS Prions    are    abnormal,    misfolded    body    proteins    that    go    out                  of     control     and     begin     to     multiply     themselves,     spreading throughout   the   body   and   invading   the   brain.      Prions   are   most commonly     transmitted     orally,     but     can     also     contaminate medical   and   surgical   instruments,   transplanted   tissues,   and equipment   used   in   food   processing.   A   new,   fast,   convenient and       safe       method       for       decontamination       of       medical instruments,   surfaces,   and   tissues by   simple   immersion   in an    aqueous    solution    of    Briotech’s    pure    BrioHOCl TM can overcome     a     critically     important     deficiency     in     infection control   today.   It   can   mitigate   risks,   and   limit   liabilities   related to healthcare procedures and hospital acquired diseases. Prion   diseases   are   most   widely   known   as   the   cause   of   Mad Cow    Disease    (BSE).    Prions    also    cause    Creutzfeldt-Jakob Disease    (CJD)    in    humans,    a    fatal    dementia    with    a    long incubation   period.   Recently,   research   has   shown   that   most other   chronic   degenerative   diseases   that   lead   to   dementia, including       Alzheimer’s,       result       from       prions.       Currently untreatable,   and   inevitably   fatal,   controversy   swirls   around their     possible     transmissibility     as     referenced     in     Nature   / / r - alzheimers ) Prions     are     uniquely     resistant     to     the     disinfection     and sterilization     procedures     in     common     use     in     healthcare practice   today.   Extreme   measures   are   needed.   Current   prion decontamination      protocols      are      hazardous      to      people, damaging     to     instruments     and     surfaces,     and     therefore impractical   for   transmission   control.   “Briotech   has   developed an   enabling   technology,   one   that   offers   for   the   first   time   a practical    and    safe    way    of    destroying    infectious    prions,    the disease    agents    at    the    very    top    of    the    food    chain    when    it comes     to     resistance     to     disinfection     measures,”     said     Jeff Williams,    PhD,    BVSc,    Chief    Scientific    Officer    at    Briotech.      “We   believe   we’ve   just   exposed   the   tip   of   the   iceberg   when        it   comes   to   revealing   the   full   potential   of   the   pure   HOCl   in controlling     and     preventing     many     transmissible     diseases. That’s      so      important      today      when      rampant      antibiotic resistance       is       challenging       established       approaches       to infectious     disease     management     all     over     the     world.     The discovery     reported     in     PLOS     Pathogens      has     opened     new avenues    for    researchers    to    explore    in    understanding    the relationship     between     the     HOCl     made     in     the     brain,     its possible    involvement    in    prion    inactivation    there,    and    the disease    processes    that    lead    to    dementia.    Understanding those   processes   is   one   of   the   most   urgent   priorities   facing biomedical science at this time.” HOW IT WORKS BrioHOCl TM    is   easy   to   handle,   safe   for   both   users   and   treated surfaces   and   is   environmentally   safe.   Pure   HOCl,      used   in   the PLOS    Pathogens     report,    is    reliably    stable    in    its    formulation and   powerfully   effective   against   a   wide   range   of   conventional microbial   disease   agents.   The   solution   can   be   applied   directly to   skin   and   mucous   membranes,   hard   surfaces,   instruments, or safely aerosolized to decontaminate entire rooms. Briotech      manufactures      BrioHOCl TM       in      fully-automated production   platforms   inside   20’   shipping   containers,   enabling production    and    distribution    of    a    consistent    and    pure    form              of HOCl virtually anywhere in the world. ABOUT BRIOTECH INCORPORATED Based    in    Woodinville,    WA,    the    company    was    founded    in 2013    to    commercialize    the    production    of    pure    HOCl,    a powerful,     safe,     naturally     occurring     substance,     effective against    the    whole    range    of    infectious    disease    pathogens                              of    humans    and    animals,    and    to    make    it    readily    available throughout        the        world.        Briotech’s        introduction        of transportable,   self-contained   manufacturing   systems   makes high    volume    production    of    consistent    and    reliable    HOCl solutions    possible    for    the    first    time    ever.    Its    proprietary electrolysis   technology   creates   unique   formulations   of   stable HOCl   for   a   wide   range   of   applications   in   consumer,   medical, agricultural     and     industrial     settings.     More     information     is available at briotechusa.com . ABOUT THE RESEARCH STUDY The   research   study   titled   “Inactivation   of   Prions   and   Amyloid seeds   with   Hypochlorous   Acid”   appears   in   the   current   issue of PLOS Pathogens  here: los.org/10.1371/journal.ppat.1005914 BrioHOCl TM treatment    led    to        a    high    level    of    inactivation after   short   exposure   times   for   transmissible   prions   of   CJD, BSE,   and   CWD,   but   also   for   self-replicating   proteins   found   in Alzheimer’s,   Parkinson’s   and   other   dementias.   Infectivity   of BrioHOCl TM treated   scrapie   prions   in   mice   was   also   highly significantly reduced.
P R E S S  R E L E A S E
B R I O H O C L P r P F O R M U L A TM
The    breakthrough   needed   to   overcome   a   critically   important deficiency   in   infection   control.   A   new,   fast,   convenient   and safe    method    for     decontamination    of    medical    instruments, surfaces,    and     tissues     by     simple    immersion    in    an    aqueous solution.   BRIO   HOCL   PrP   Formula TM     is   a   proven   anti-prion reagent    to    combat    misfolded    infectious    proteins,    and    the recommended   proprietary   disinfection   solution   to   combat   all misfolded   infectious   proteins.   This   patent   pending   product   is available  for research use.
“I     think     it     [BRIO                    HOCL TM ]     will     have     an     extraordinary important    application    in    the    world     Byron    Caughey,    a    senior investigator    at    the    National    Institute    of    Allergy    and    Infectious    Diseases,                                  a division of the National Institutes of Health.
U N M A T C H E D  I N  P U R I T Y  A N D  S T A B I L I T Y
a proprietary     PrP Formula TM          by Briotech
PROVEN EFFECTIVE FOR INACTIVATION OF PRIONS AND OTHER MISFOLDED INFECTIOUS PROTEINS FOR RESEARCH & INVESTIGATIONAL USE ONLY
®